Why I Take Low-Dose Tirzepatide (& Not Retatrutide)

Dr. Brad Stanfield — Why I Take Low-Dose Tirzepatide (& Not Retatrutide)

Channel: Dr Brad Stanfield · Our label: Physician educator — skeptical, evidence-first voice · Source: youtube.com/watch?v=yKPaVhpomks

What this video covers

I’m not overweight, and there was no randomized clinical trial that said I should be doing this. Every trial that you may have heard of, so select or flow, surpass, COVT, they enrolled people with diabetes, obesity, kidney disease, or established heart disease. So, when John Eng found GLP-1 in the saliva of the Gila monster in the early 1990s, all it was supposed to do was lower blood sugar. He was an endocrinologist in Bronx VA, and he was working on lizard venom in his spare time.

Summary drawn from this video’s own transcript (banked in our research library, pulled 2026-11-07). Claims below are the speaker’s — attributed, not endorsed. This site publishes no dosing, protocol, or sourcing information.

Key points, in the speaker’s own framing

• I’m not overweight, and there was no randomized clinical trial that said I should be doing this.
• But, the peptide that he isolated, it acts on the same receptor as the human GLP-1, but it lasts much longer in the body.
• And by the mid-2010s, the SCALE trial had confirmed that liraglutide, which is another type of GLP-1 medication, caused significant weight loss.
• And now, there’s even new evidence that GLP-1 medications are associated with a reduction in cancer progression.
• But then patients on GLP-1 medications, specifically this time Ozempic, they started saying something that the doctors initially dismissed, that their joints felt better.
• But what we’ve discussed so far is evidence for GLP-1 medications, but I chose to use tirzepatide, which is a combination of GLP-1 and GIP.

Read next

• GLP-1 class — more videos
• Semaglutide — more videos
• Tirzepatide — more videos
• Retatrutide — more videos
• Liraglutide — more videos
• All videos from this channel

Educational information only — not medical advice. Peptides discussed on this page include substances that are not FDA-approved.