People Are Losing Muscle on Retatrutide. Dr. Shows How to Avoid

This Is Not Covered — Dr. Ashley Froese — People Are Losing Muscle on Retatrutide. Dr. Shows How to Avoid

Channel: This Is Not Covered - Dr. Ashley Froese · Our label: Clinician educator · Source: youtube.com/watch?v=Tm2wuMZQnvU

What this video covers

Most people using GLP-1 drugs like retatrutide are losing not just fat, but lean body mass, too. Muscle, strength, [music] and in some cases, up to 40% of the weight they lose isn’t fat at all. The scary part, most people don’t realize it’s happening until months later when their metabolism has slowed down and their strength is down and they feel weaker than before they started. But here’s what almost nobody is talking about.

Summary drawn from this video’s own transcript (banked in our research library, pulled 2026-11-07). Claims below are the speaker’s — attributed, not endorsed. This site publishes no dosing, protocol, or sourcing information.

Key points, in the speaker’s own framing

• Most people using GLP-1 drugs like retatrutide are losing not just fat, but lean body mass, too.
• I’ve been working with GLP-1 drugs for over 5 years now, and retatrutide really has captured my attention as a potential cure-all for anyone dealing with extra weight or inflammation.
• [music] It activates GLP-1, GIP, and glucagon receptors in the body, producing some of the most dramatic weight loss results we’ve ever seen in clinical trials.
• And this also lines up with the studies on fat versus lean tissue loss using all of the GLP-1 agonists semaglutide tirzepatide and retatrutide, roughly.
• But before I do, I want to talk to you about one of the most misunderstood things about using GLP-1 drugs and the side effects that can [music] go along with it.
• So, if someone is using retatrutide, even if they’re not supposed to be, or another GLP-1 agonist like semaglutide or tirzepatide, or if you’re just on a weight loss journey in general, what happens is that insulin levels fall.

Read next

• GLP-1 class — more videos
• Semaglutide — more videos
• Tirzepatide — more videos
• Retatrutide — more videos
• All videos from this channel

Educational information only — not medical advice. Peptides discussed on this page include substances that are not FDA-approved.